Hartemink Nienke

Nienke HarteminkNienke Hartemink: Since successfully completing her PhD within the original EDEN FP6 Project as part of the Mathematical Modelling Team. Nienke has successfully published a number of papers on modelling R0 and Vector-Borne Disease and is building a well respected reputation in her field of study.

Short description of project activities:

Mathematical modelling and risk mapping for several pathogens considered in EDENext. Currrent topics:


  • Effect of habitat fragmentation on disease transmission,
  • An agent-based model for Puumala virus (ROBO)
  • Leishmaniasis risk maps in Turkey
  • Spatial population models for Aedes albopictus
  • Tick-borne diseases, population dynamics and models

Main skills:

Mathematical modelling, epidemiology, ecology, GIS


N. Hartemink, S. O. Vanwambeke, H. Heesterbeek, D. Rogers, D. Morley, B. Pesson, C. Davies†, S. Mahamdallie, P. Ready. Integrated Mapping of Establishment Risk for Emerging Vector-Borne Infections: a Case Study of Canine Leishmaniasis in Southwest France. PLoS ONE 6(8): e20817. doi:10.1371/journal.pone.0020817

N.A. Hartemink, B.V. Purse, R. Meiswinkel, H.E. Brown, A. de Koeijer, A.R.W. Elbers, G.-J. Boender, D.J. Rogers and J.A.P. Heesterbeek, 2009. Mapping the basic reproduction number (R0) for vector-borne diseases: A case study on bluetongue virus. Epidemics 1 (3), 153-161.

A.A. Matser*, N.A. Hartemink*, J.A.P. Heesterbeek, A. Galvani and S.A. Davis, 2009. (*These authors contributed equally to this work). Elasticity analysis in epidemiology: an application to tick-borne infections. Ecology Letters 12 (12), 1298–1305

Hartemink, N. A., Randolph, S. E., Davis, S. A. and Heesterbeek, J. A. P. 2008. The basic reproduction number for complex disease systems: defining R0 for tick-borne infections. The American Naturalist 171, 743–754.

Hartemink, N. A., Davis, S. A., Reiter, P., Hubálek, Z. and Heesterbeek, J. A. P. 2007. The importance of bird-to-bird transmission for the establishment of West Nile virus. Vector- Borne and Zoonotic Diseases 7 (4): 575-584

N. Hartemink, H. C. Boshuizen, N. J. D.Nagelkerke, M. A. M. Jacobs and H. C. van Houwelingen, 2006. Combining risk estimates from observational studies with different exposure cutpoints: a meta-analysis on body mass index and diabetes type 2.   American Journal of Epidemiology 163, 1042-1052.

N. Hartemink, E. Jongejans, and H. de Kroon, 2004.  Flexible life history responses to flower and rosette bud removal in three perennial herbs.  Oikos 105; 159-167.

Books, or contributions to books:

N.A. Hartemink and J.A.P. Heesterbeek. Modelling R0 for environmental change.
Book chapter in: Global Environmental Change and Infectious Diseases, Impacts and Adaption Strategies, edited by Sauerborn, R. and Louis, V. R., Springer, 2009.

Integrated Mapping of Establishment Risk for Emerging Vector-Borne Infections: a Case Study of Canine Leishmaniasis in Southwest France


Zoonotic visceral leishmaniasis is endemic in the Mediterranean Basin, where the dog is the main reservoir host. The disease’s causative agent, Leishmania infantum, is transmitted by blood-feeding female sandflies. This paper reports an integrative study of canine leishmaniasis in a region of France spanning the southwest Massif Central and the northeast Pyrenees, where the vectors are the sandflies Phlebotomus ariasi and P. perniciosus.

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